Enantioselective total synthesis of (R)-(−)-complanine
نویسندگان
چکیده
A route is described for the enantioselective synthesis of (R)-(-)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.
منابع مشابه
(−)-Complanine, an inflammatory substance of marine fireworm: a synthetic study
The synthesis of (-)-complanine, an inflammatory substance of Eurythoe complanata, was accomplished by a "chiral synthon" approach. The absolute configuration of this molecule was determined to be R.
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